Mumbai: Domestic stock markets started with fall of 300 points on Bombay Stock Exchange as the November derivatives series took off on a weak note amid negative Asian cues. 

At 10.15 AM the 30-share BSE Sensex traded 189.74 points or 0.56% lower at 33,500.35, and while the wider NSE Nifty was down 69.85 points or 0.69% at 10,055.05.

In the forex market, the rupee weakened by 17 paise to 73.44 against the US dollar in early trade.
All sectoral indices, led by metal, power, realty and bank stocks were trading in the negative territory. 

Of 30 Sensex stocks, 22 were trading in the red in the morning trade. Top losers in the 30-share Sensex pack were Yes Bank (-6.20%), NTPC (-3.92%), Asian Paints (-2.52%), Vedanta (-2.52%), TCS (-1.74%) and Coal India (-1.65%). 
Heavyweights Infosys, TCS and ITC contributed most to the losses.

Globally, Asian shares slipped again on Friday morning, deepening this week's markets rout, after disappointing results from Alphabet Inc and heightened concerns over the outlook for U.S. corporate earnings, global trade and economic growth.